Ahmed S. - Managing Director/ Medical Lead - Global Bio-pharma A difference between the interRR of the PGA assessed by an untrained physician (ICC=0.50.63) or a trained investigator (ICC=0.790.81) was found [36]. Introduction Physician global assessments of disease activity (medical doctor (MD) globals) are important outcomes. IgM) on attainment PhGA. , Kostopoulou M
The last MEDLINE search was performed on 1 July 2019. Physician training is very important. , Sayedbonakdar Z
, Magder LS
The PGA was integrated in composite indices, including the definition of the LLDAS [12, 13, 29, 34, 37, 39, 40] and remission [29, 37] (Table1). There is no cure for lupus, but medical . Comparison of the validity and sensitivity to change of 5 activity indices in systemic lupus erythematosus. , Nguyen SC
PDF Physician s global assessment is often useful in SLE, but not always , Birmingham DJ
, Morabito LM
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Immune Disorders, Deficiency, Etc - Key Points to Review: Initiation of Objective Physician's global assessment (PGA) of disease activity is a major determinant of therapeutic decision making. 2014 Sep-Oct;10(5):309-20. doi: 10.1016/j.reuma.2014.01.012. Published by Oxford University Press on behalf of the British Society for Rheumatology. 2) [10, 23, 24, 26, 28, 29, 35, 54, 68, 76, 84, 99], with the SLAM in 4 studies (r=0.470.65) [35, 76, 84, 99], with LAI in 2 studies (r=0.640.75) [68, 84], with BILAG in 2 studies (r=0.610.62) [35, 84] and with ECLAM in 2 studies (r=0.580.65) [35, 84]. , Kraag GR
Mok CC
, Fortin PR
, Tetzlaff J
Systemic Lupus Erythematosus and Lupus Nephritis - Epidemiology Psychometric properties of FACIT-Fatigue in systemic lupus erythematosus: a pooled analysis of three phase 3 randomised, double-blind, parallel-group controlled studies (BLISS-SC, BLISS-52, BLISS-76). , Mohan C. Giangreco D
et al. To determine longitudinal associations between Physician Global Assessment (PGA) and patient-reported outcomes (PROs) in patients with systemic lupus erythematosus (SLE). Psychometric properties data were analysed according to the OMERACT Filter methodology version 2.1. A Comprehensive Digest of Research Publications From Cedars-Sinai Investigators. Jesus D
A prospective cohort study, Validity and reliability of retrospective assessment of disease activity and flare in observational cohorts of lupus patients, A novel lupus activity index accounting for glucocorticoids: SLEDAI-2K glucocorticoid index, Low disease activityirrespective of serologic status at baselineassociated with reduction of corticosteroid dose and number of flares in patients with systemic lupus erythematosus treated with belimumab: a real-life observational study, Definition and initial validation of a lupus low disease activity state (LLDAS), A framework for remission in SLE: consensus findings from a large international task force on definitions of remission in SLE (DORIS), Prolonged remission in Caucasian patients with SLE: prevalence and outcomes, 2019 update of the EULAR recommendations for the management of systemic lupus erythematosus, PRISMA Group. Laboratory investigation results influence Physicians Global ssessment (PGA) of disease activity in SLE. Touma Z
Parodis I
An international panel of 79 SLE experts participated in a three-round Delphi consensus process, in which 41 statements related to the PGA in SLE were . , Kalunian K
, Landis RC
, Henriques C
Faculty Publications: Feb. 23-March 2 The Handheld Dermatoscope as a Nail-Fold Capillaroscopic Instrument - JAMA All versions are validated and used by lupus researchers for clinical and research purposes. This scoring modality was used for the SRI [3]. All rights reserved. X 20 Physician Global Assessment 10.1136/lupus-2019-lsm.176 . How should lupus flares be measured? T2 - A longitudinal study. Jiao H, Acar G, Robinson GA, Ciurtin C, Jury EC, Kalea AZ. Definition: At least a 20%, 40%, 50%, or 70% improvement and an absolute improvement of at least 1 unit on a scale of 1-10 in at least three of the following criteria: patient global assessment; pain; function (BASFI); and. , Urowitz MB
Ruiz-Irastorza G
Rheumatology (Oxford). The literature search identified 91 studies. The Physician Global Assessment (PGA) is a visual analogue score that reflects the clinician's judgement of overall SLE disease activity.
Exagen Diagnostics Inc (XGN) - Product Pipeline Analysis, 2022 Update Each study was examined in order to extract psychometric property data on the PGA according to the OMERACT Filter methodology version 2.1 [18]. et al. Petri M
, Andreoli L
Exagen's products are used for therapeutic drug monitoring of hydroxychloroquine in whole blood and methotrexate polyglutamates, risk assessment testing, anti-TNF monitoring to individualize therapy and optimize dosing, and others. Gladman DD
antineutrophil cytoplasmic antibody-associated vasculitis (AAV), and systemic lupus erythematosus (SLE). , Mikolaitis-Preuss RA
, Adamichou C
PGA or SGA described in ePROVIDE - Mapi Research Trust et al. Methods: 2022 May;9(1):e000700. Elisabetta Chessa, Matteo Piga, Alberto Floris, Herv Devilliers, Alberto Cauli, Laurent Arnaud, Use of Physician Global Assessment in systemic lupus erythematosus: a systematic review of its psychometric properties, Rheumatology, Volume 59, Issue 12, December 2020, Pages 36223632, https://doi.org/10.1093/rheumatology/keaa383.
Using the Physician Global Assessment in a clinical setting to - PubMed Matthew Turk,1,2 Janet E Pope1,2 To cite: turk M, Pope Je. In this sense, criterion validity of PGA is satisfied when scores correlate with phenomena subsequently influenced by disease activity, such as quality of life measurements (Health-related Quality of Life, 36-item Short Form Health Survey, Functional Assessment of Chronic Illness TherapyFatigue score, Lupus Impact Tracker and LupusPRO), biomarker levels (complement fractions, ESR, autoantibodies), treatment variations and damage assessments (SDI). et al. Because of its dynamic nature, this disease has an unpredictable natural course leading to high . Genetic linkage has related dysfunction of . When expanded it provides a list of search options that will switch the search inputs to match the current selection. Few studies reported on whether serological activity should be incorporated in the PGA. Moreover, a difference between the interRR of the PGA assessed by an untrained physician (0.50.63) and a trained investigator (0.790.81) was found, suggesting the need for PGA scoring training or standardization [36]. , Chan KL
, Petri M. Thanou A
Physician's global assessment is often useful in SLE - ResearchGate disease activity). Schneider M
LECTURE 10: MEDICAL SURGICAL NURSING. Face validity. , Gladman DD
In most studies, the PGA was assessed by a rheumatologist experienced in SLE care or research and, as already stated, the ICC reliability was different for an untrained physician and a trained investigator [36]. A new tool -- the Lupus Activity Scoring Tool (LAST) - has been proposed to join the ranks of current disease activity indices. In Fatemi et al. , Holland M
SLE3. Accessibility , Sjwall C
Construct validity is shown by the good correlation observed with the SLEDAI, BILAG, SLAM, LAI and ECLAM [10, 23, 24, 26, 28, 29, 35, 54, 68, 76, 84, 99]. An assessment of disease flare in patients with systemic lupus erythematosus: a comparison of BILAG 2004 and the flare version of SELENA. Piga M
Five centres in Great Britain and the Republic of Ireland have collaborated to produce a computerized index of clinical disease activity in systemic lupus erythematosus, based on the principle of the physician's intention to treat. Federal government websites often end in .gov or .mil. FOIA , Chatzidionysiou K
, Leung HW
Kiani AN
, Rairie JE
, Farewell V
et al. A good correlation was considered for a value >0.60. A good responsiveness for PGA was shown in eight studies. , Rodrigues M
What Does It Mean to Be a British Isles Lupus Assessment Group-Based et al. The anonymous patientcompleted questionnaire comprised the following: current pain in the past 7 days (10cm VAS [0 no pain; 10 most severe pain]), patient global assessment (PtGA) of health status (10 cm VAS [0 very well; 10 very poorly]), ever and current recreational cannabis use, ever and current medical cannabis use, and if cannabis . 2014 Dec;53(12):2175-81. doi: 10.1093/rheumatology/keu153. , Tanangunan R
Physician global assessment in systemic lupus erythematosus: Can we , Buyon J
Scoring systemic lupus erythematosus (SLE) disease activity with simple Provide oversight to Shared Services Derivatives team supporting RWA operations and production. Deconstruction of the safety of estrogen in lupus erythematosus national assessment-systemic lupus erythematosus disease activity index flare index, Effect of raloxifene on disease activity and vascular biomarkers in patients with systemic lupus erythematosus: subgroup analysis of a double-blind randomized controlled trial, Omega-3 in SLE: a double-blind, placebo-controlled randomized clinical trial of endothelial dysfunction and disease activity in systemic lupus erythematosus, Erythrocyte sedimentation rate is a predictor of renal and overall SLE disease activity, Characterization of clinical photosensitivity in cutaneous lupus erythematosus, Validation of the systemic lupus erythematosus responder index for use in juvenile-onset systemic lupus erythematosus, Depressive symptoms and associated factors in systemic lupus erythematosus, Validation of the Portuguese simple measure of impact of lupus erythematosus in youngsters (SMILEY) in Brazil, Anti-C1q antibodies have higher correlation with flares of lupus nephritis than other serum markers, Performance of anti-C1q, antinucleosome, and anti-dsDNA antibodies for detecting concurrent disease activity of systemic lupus erythematosus, An assessment of disease flare in patients with systemic lupus erythematosus: a comparison of BILAG 2004 and the flare version of SELENA, Noncalcified coronary plaque in systemic lupus erythematosus, Decreases in anti-double-stranded DNA levels are associated with concurrent flares in patients with systemic lupus erythematosus, Validity and reliability of lupus activity measures in the routine clinic setting, Clinical predictors of response and discontinuation of belimumab in patients with systemic lupus erythematosus in real life setting. , Altman DG
Fanouriakis A
It was published in 1977 and was initially designed for the measurement of self-assessed pain in rheumatoid arthritis although it has since been used to evaluate RA more globally.
04 Measuring SLE disease activity in 2020: perspectives from clinical A PGA 2 correlated with a risk of pregnancy loss (29% vs 8%, P=0.005) [49]. More frequently, responsiveness was assessed by correlating changes in the PGA with changes in other scores [23, 50, 58, 77, 78, 81, 83], finding a significant correlation with variations in the SLEDAI (r=0.390.66) [23, 77, 78], SLAM (0.61) [77], LAI (0.56) [77], patient global assessment (0.37) [77], SRI-50 (0.48) [78] and ESR (P<0.0001) [58], but not with C3, C4, circulating immunocomplexes and prednisone dose [77].